NMR identification of ligands of aminoglycoside resistance enzymes
نویسندگان
چکیده
منابع مشابه
NMR identification of ligands of aminoglycoside resistance enzymes
Bacterial resistance to aminoglycosides is mainly the result of enzyme-catalysed chemical modifications of these antibiotics, which prevents their binding to their target. In order to circumvent this mechanism, an attractive possibility would be to block these enzymes, using selective inhibitors. This work describes a rational strategy aimed at isolating specific ligands of these enzymes, using...
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ژورنال
عنوان ژورنال: Comptes Rendus Chimie
سال: 2006
ISSN: 1631-0748
DOI: 10.1016/j.crci.2005.06.011